Gene mutations and aneuploidy: The instability that causes cancer

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Abstract

Cancer cells have been characterized with activated mutant oncogenes and inactivated or deleted tumor suppressor genes. Cancer cells are also aneuploid, displaying a jumble of chromosomal anomalies including gain or loss of whole chromosomes or transposed chromosomal fragments. Whether mutation of specific genes or aneuploidy is more critical for tumorigenesis is very much a contentious issue. We recently showed that activated oncogenes induce oxidative damage that is exacerbated by conventional cell culture conditions. This "culture shock" or a loss of p53 function creates a precarious environment that permits oncogenes to induce rapid chromosomal instability and transformation. We found that mutant genes and aneuploidy were prerequisites and collaborators for neoplastic transformation.

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Woo, R. A., & Poon, R. Y. C. (2004). Gene mutations and aneuploidy: The instability that causes cancer. Cell Cycle. Taylor and Francis Inc. https://doi.org/10.4161/cc.3.9.1089

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