Immunologic Response to the Nitro-Olefins

Abstract

The conjugated nitro-olefins have been shown to be effective agents in provoking delayed hypersensitivity in guinea pigs. Studies of a variety of substituted and unsubstituted, saturated and unsaturated hydrocarbons indicate that only the conjugated, nitro-substituted compounds are sensitizers. Examination of cross-reactivity between nitro-olefins of differing chain length indicates that specificity of the contact reactions is dependent, at least in part, upon the size of the haptenic moiety.