A new frontier for nondestructive spatial analysis of pharmaceutical solid dosage forms: Spatially offset low-frequency Raman spectroscopy

Abstract

A new Raman subtechnique, spatially offset low-frequency Raman spectroscopy (SOLFRS), is demonstrated via an analysis of pharmaceutical solid dosage forms. Several different model systems comprised of celecoxib (a popular anti-inflammatory drug), α-lactose anhydrous stable form, α-lactose monohydrate, and polyvinylpyrrolidone (PVP) were used to represent tangible scenarios for the application of SOLFRS. Additionally, the challenges and limitations were highlighted in relation to its real-time use, and potential solutions to address them were also provided. Lastly, the future directions for this new variation of Raman spectroscopic technique were briefly discussed, including its potential for broader application in pharmaceutical analysis and other research fields.