Multisystem inflammatory syndrome in children associated with 2019 novel coronavirus (SARS-CoV-2) infection

Abstract

Being in the middle of a global pandemic of coronavirus disease (COVID-19), caused by the novel coronavirus SARS-CoV-2 there were never ending speculation regarding the occurrence, causation, spread and treatment of the disease which warranted a never ending research on this aspect. Initially was thought to be affecting children with lesser severity, but now it has been observed that, SARS-CoV-2 infection has recently been associated with a novel set of clinical manifestations presently called multisystem inflammatory syndrome in children (MIS-C) which was recognised at the outset by the United States, which lacked published reports by then. Here, we describe three critically ill patients with the spectrum of MIS-C associated with SARS CoV- 2 infection presenting to a tertiary-care center in India. Clinical presentation of MIS-C with multi-organ involvement and elevated inflammatory markers may have a presentation which is similar to the presentation as seen in Kawasaki disease and toxic shock syndrome. But now it has been presently understood to be a separate phenomenon and it has been related to a post-viral immune-mediated inflammatory process, and the pathogenesis of the occurrence of this syndrome complex still remains unclear.