A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Abstract

Colorectal cancer risk can be impacted by genetic, environ-SNP was also identified by the 3DF test, with a suggestive statimental, and lifestyle factors, including diet and obesity. Genestical significance in the 1DF test. Among participants with the environment interactions (G × E) can provide biological insights CC genotype of rs58349661, overweight and obesity categories into the effects of obesity on colorectal cancer risk. Here, we were associated with higher colorectal cancer risk, whereas null assessed potential genome-wide G × E interactions between body associations were observed across BMI categories in those with mass index (BMI) and common SNPs for colorectal cancer risk the TT genotype. Using data from three large international using data from 36,415 colorectal cancer cases and 48,451 con-consortia, this study discovered a locus in the FMN1/GREM1 trols from three international colorectal cancer consortia (CCFR, gene region that interacts with BMI on the association with CORECT, and GECCO). The G × E tests included the convencolorectal cancer risk. Further studies should examine the potentional logistic regression using multiplicative terms (one degree tial mechanisms through which this locus modifies the etiologic of freedom, 1DF test), the two-step EDGE method, and the joint link between obesity and colorectal cancer. 3DF test, each of which is powerful for detecting G × E interactions under specific conditions. BMI was associated with higher Significance: This gene-environment interaction analysis colorectal cancer risk. The two-step approach revealed a statisrevealed a genetic locus in FMN1/GREM1 that interacts with body tically significant G×BMI interaction located within the Formin mass index in colorectal cancer risk, suggesting potential implica-1/Gremlin 1 (FMN1/GREM1) gene region (rs58349661). This tions for precision prevention strategies.