Effect of oral administration of aqueous leaf extract of Momordica charantia (bitter melon) on serum glucose, and lipid profile in alloxan-induced diabetic rats

Abstract

Momordica charantia (bitter melon) has been used extensively in herbal medicine as remedy for many disease conditions. The present study was undertaken to evaluate the effect of Momordica charantia (MC) aqueous leaf extract on serum fasting blood glucose (FBG) and lipid profile (total cholesterol TC, triglyceride TAG, high density lipoprotein HDL, low density lipoprotein LDL) in alloxan-induced diabetic rat. The extract was administered orally at the dose of 200mg/kg, 400mg/kg, and 600mg/kg body weight either for a period of 2 or 4 week. A significant (p<0.05) improvement in the biochemical parameters such as FBG, TC, TAG, HDL, and LDL levels was observed in MC treated rats as compared to diabetic control rats. The response to treatment was gradual and dose-dependent with maximum effect at higher dose of 600mg/kg body weight for 4 weeks.