Successful Continuous Treatment with All-Trans Retinoic Acid for Acute Promyelocytic Leukemia; Secondary Malignancy after the Treatment of Osteosarcoma

Abstract

We report a rare case of complete remission for 32 months with continuous treatment with all-trans retinoic acid (ATRA) alone in a patient with acute promyelocytic leukemia which developed as a second malignancy after the treatment of osteosarcoma after failure of conventional chemotherapy. The adverse effects of ATRA were apparently tolerable. © 1994, The Japanese Society of Internal Medicine. All rights reserved.