Oral Administration of lactobacillus plantarum NRIC0380 suppresses IgE production and induces CD4+CD25+Foxp3+ Cells in Vivo

Abstract

The influence of lactic acid bacteria (LAB) on CD4+Foxp3 + cells has not been investigated, although it has been reported that CD4+Foxp3+ cells might be involved in the inhibition of allergic symptoms. Hence we examined the effect of orally administered LAB on CD4+Foxp3+ generation. Oral administration of Lactobacillus plantarum NRIC0380 significantly inhibited antigen-specific IgE production and enhanced the Th1 response, as some other strains reported in previous studies. The ratio of CD4+CD25+Foxp3+ cells in whole CD4+ cells was significantly higher in both Peyer's patch and the spleen of mice that had been fed with LAB than in the control mice.