Effect of urea and TMAO on lipid bilayers

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Abstract

We study the effect of the osmolytes, Urea and trimethylamine-N-oxide (TMAO) on POPE (1-palmitoyl-2-oleoyl-sn-glycero-3- phosphoethanolamine) lipid membranes using SAXS/WAXS and DSC. Their antagonist effect is observed with TMAO stabilizing and Urea destabilizing the lipid bilayer, as seen by others in earlier researches.

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Valerio, J., Bernstorff, S., & Funari, S. S. (2017). Effect of urea and TMAO on lipid bilayers. European Pharmaceutical Journal, 64(2), 24–27. https://doi.org/10.1515/afpuc-2017-0003

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