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Two Fatal Cases of Acute Liver Failure Due to HSV-1 Infection in COVID-19 Patients following Immunomodulatory Therapies

Clinical Infectious Diseases (2021) 73(1) E252-E255
DOI: 10.1093/cid/ciaa1246
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Abstract

We report two fatal cases of acute liver failure secondary to herpes simplex virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy. Screening for and prompt recognition of herpes simplex virus 1 reactivation in these patients, undergoing immunomodulatory treatment, may have potentially relevant clinical consequences.

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Busani, S., Bedini, A., Biagioni, E., Serio, L., Tonelli, R., Meschiari, M., … Fregni Serpini, G. (2021). Two Fatal Cases of Acute Liver Failure Due to HSV-1 Infection in COVID-19 Patients following Immunomodulatory Therapies. Clinical Infectious Diseases, 73(1), E252–E255. https://doi.org/10.1093/cid/ciaa1246

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