Effects of ciplukan (Physalis angulata l.) juices on lipid profile status and histopathological of liver in rats with streptozotocin diabetes

Abstract

Type 2 diabetes mellitus (T2DM) is associated with an abnormal lipid profile. Several functional foods have therapeutic potential for treating chronic diseases, including diabetes. One plant that has this therapeutic potential is Physalis angulata or ciplukan. This study aimed to evaluate the effects of P. angulata juice drink (PJ) on the levels of plasma lipid profiles and health of the liver in streptozotocin (STZ) induced T2DM Wistar rats. Twenty healthy male Wistar rats were induced to diabetes with a single dose intraperitoneal administration of STZ (40 mg/kg b.w.). Diabetic rats were orally administered with 1 mL/day of ciplukan juice (D-T1) or 2 mL/day of ciplukan juice (D-T2) or 62.5 mg/kg b.w. of metformin every day for 14 days. Rats in all groups were sacrificed on day 14. PJ lowered triglyceride (TGs) significantly (P<0.05), but not for total cholesterol (TC) compared to the diabetic group (negative control). Moreover, the administration of PJ significantly increased the levels of HDL-cholesterol (HDL-c) (P<0.05). Oral administration of P. angulata juices and metformin drug to diabetic rats significantly reversed all these changes to near-normal levels. In conclusion, the active constituents with high antioxidant properties in PJ might be responsible for its anti-hyperlipidaemia and anti-inflammatory effects, as well as the restoration effect on the damaged liver in experimental rats. Hence, these PJ treatments indicated their helpful effects in the amelioration of diabetes-associated complications.