Chemical constituents from Oroxylum indicum (L.) Kurz of Nepalese Origin

Abstract

From the stem bark of Oroxylum indicum, three flavones namely baicalein (1), oroxylin (2) and pinostrobin (3) along with one sterol, Stigmast-7-en-3-ol (4) were isolated and their structures were established by the use of spectroscopic techniques. Baicalein (1) and oroxylin (2) were found to be active against brine shrimp with LC50 value 10.0 μg/ml and 36.0 μg/ ml and also exhibited the antimicrobial activity on both Gram-positive and Gram-negative bacteria with MIC value 4.0 mg/ml and 8.0 mg/ml respectively. Key words: Oroxylum indicum; Flavones; Baicalein; Brine-shrimp bioassay. DOI: 10.3126/sw.v8i8.3852 Scientific World Vol.8(8) 2010 pp.66-68