Prognostic significance of received relative dose intensity in non-Hodgkin's lymphoma patients: Application to LNH-87 protocol

Abstract

Background: To evaluate the effects of chemotherapy dose intensity (DI) on outcome in patients with aggressive lymphoma, the received relative DI (received RDI) is usually calculated using Hryniuk's model. We applied this model to a selected patient subgroup included in the LNH87 protocol (LNH87-2 protocol), who had been treated with the ACVB induction regimen.Patients and methods: Patients aged ±55 who had at least one of the following prognostic factors: performance status (PS) ≥2, number of extranodal sites ≥2, tumor burden ≥10 cm, bone marrow or central nervous system involvement, and Burkitt's or lymphoblastic histologic subtype, were included in this study. Actual DI was calculated using the definition of DI as mg/m2/week previously described by Hryniuk.Results: Eighty-seven of the 311 patients included in the study (28%) presented a RDI below 70% of the theoretical DI. We demonstrated a decreased response rate (65% vs. 79%, p = 0.01) and shorter overall 2-year survival (61% vs. 72%, p = 0.02) in patients receiving a DI ±70%. This difference was still significant when the multiparametric analysis was used (p = 0.004).Conclusion: Results obtained when this model was applied to aggressive lyhoma patients included in the LNH-87 protocol led to the demonstration of a strong relationship between received RDI and survival. © 1993 Kluwer Academic Publishers.