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Epiblast Formation by TEAD-YAP-Dependent Expression of Pluripotency Factors and Competitive Elimination of Unspecified Cells

Developmental Cell (2019) 50(2) 139-154.e5
DOI: 10.1016/j.devcel.2019.05.024
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Abstract

Pluripotent epiblast is formed during preimplantation development. Hashimoto and Sasaki show that TEAD-YAP is activated and induces pluripotency factors in the forming epiblast cells. TEAD activity and pluripotency factor expression are highly variable, and cell competition eliminates unspecified cells to ensure the production of a high-quality epiblast.

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Hashimoto, M., & Sasaki, H. (2019). Epiblast Formation by TEAD-YAP-Dependent Expression of Pluripotency Factors and Competitive Elimination of Unspecified Cells. Developmental Cell, 50(2), 139-154.e5. https://doi.org/10.1016/j.devcel.2019.05.024

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