Homogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymers

Abstract

Methylstilbene-alt-maleic acid copolymers spontaneously convert biological membranes into bilayer discs with ~20 nm diameters. This readily functionalizable class of copolymers has the compositional homogeneity, hydrophobicity, dynamics, and charge that may help to achieve optimal structural resolution, membrane dissolution, stability, and broad utility.