Retinal Microvascular Resistance Estimated From Waveform Analysis Is Significantly Higher in Diabetic Retinopathy

Abstract

Purpose: Diabetic retinopathy (DR) is a typical complication in patients with diabetes. This study aimed to compare retinal blood flow and vascular resistance between eyes with DR and healthy eyes using laser speckle flowgraphy (LSFG). Methods: In total, 50 normal eyes and 87 DR eyes were examined at Kagawa University Hospital. LSFG was used to measure the mean blur rate (MBR) and total capil-lary resistance (TCR) of large vessels in the optic papilla. These values were compared across normal eyes and all eyes with DR, moderate nonproliferative diabetic retinopa-thy (NPDR), severe NPDR, and proliferative diabetic retinopathy (PDR). A TCR receiver operating characteristic (ROC) curve was plotted, and the diagnostic ability of the TCR for DR was determined using the area under the curve. The TCR cutoff value was determined using the Youden index. Results: No significant difference in MRB was observed between normal eyes and the other groups. TCR was significantly higher in all groups except the PDR group, compared to normal eyes. The TCR area under the ROC curve was 0.751, indicating moderate diagnostic accuracy for DR. Using the Youden index, the TCR cutoff value was 0.79 (sensi-tivity, 0.740; specificity, 0.701). Conclusions: Measuring TCR, in addition to MBR, as diagnostic markers provides more detailed pathological information regarding DR. Translational Relevance: Comparison of values between groups would be useful in predicting DR onset and stage progression.