RBC storage lesions

Abstract

In this issue of Blood, Reisz et al present a proteomic and metabolomic analysis of red blood cells (RBCs) stored in Additive Solution 3 that focuses on the oxidative changes in the active sites of glyceraldehyde 3-phosphate dehydrogenase (GAPDH). The changes accumulate and become irreversible with time but are sufficiently infrequent that it is unclear that they matter for posttransfusion function.