Synthesis of N-containing heterocycles via mechanochemical grinding and conventional techniques

Abstract

Mechano heterocyclic chemistry is a recent quickly growing technique draws the attention of hetrocyclic chemists towards the use of grindstone technique in a solvent free green efficient clean synthesis of many heterocyclic systems. α,β-Epoxy ketones were used as a unique scaffold for synthesis of stable hydroxyazoles. The key advantage of grinding technique over the conventional thermal technique includes its simple, solvent free conditions, as well as facile work up with high yield economy. It is also successful in achieving three of the green chemistry objectives of a solvent free, high atom economy, save energy thus combining the features of both economic and environmental advantages.