Greener and efficient one-pot synthesis of novel multi-substituted 3-(4,5-diphenyl1h-imidazol-2-yl)-1h-indole derivatives by using recyclable catalyst under microwave irradiation

Abstract

The novel class of multi-substituted indolylimidazole derivatives series substituted 3-(4,5diphenyl-1H-imidazol-2-yl)-1H-indole and substituted 5-bromo-3-(4,5-diphenyl-1Himidazol-2-yl)-1H-indole was synthesized utilising a green and efficient one-pot four components condensation of indole-3-carbaldehyde, benzil, ammonium acetate and various amines under microwave irradiation using Amberlyst A-15 as a recyclable catalyst. The catalyst Amberlyst A-15 has recovered from the reaction mixture and reused repeatedly for the next reaction. The key advantage of this process involves eco-friendly, very short reaction time, cost-effectiveness with the reusability of catalyst, easy workup, and purification of the product with excellent yields. FTIR,1HNMR and Mass spectrometric studies analyzed and established the structures of all newly synthesized compounds.