Clinical observations of osteoporotic vertebral compression fractures by using mineralized collagen modified polymethylmethacrylate bone cement

Abstract

To investigate the clinical outcomes of the treatment of osteoporotic vertebral compression fractures (OVCFs) by using mineralized collagen (MC) modified polymethylmethacrylate (PMMA) bone cement. 52 cases (52 vertebras) who sustained OVCF treated with MC modified PMMA bone cement from July 2014 to December 2015 were reviewed retrospectively. All the cases (52 patients, 52 vertebras) included 8 males and 44 females with an average age of 74.83 (ranging from 57- to 90-years old). The visual analogue scale (VAS), vertebral body height, Cobb angle, CT values preand post-operation as well as incidence of complications were used to be observed. All the patients underwent the surgery were successfully followed-up with an average period of 13.54 months (ranging from 6 to 23 months). The patients can ambulate at the second day after the operation. The VAS scores 2 days after the operation and during the last follow-up were significantly decreased compared with that before the operation (P < 0.05); the average vertebral height and local Cobb angle had significant recovery (P < 0.05); the CT value of the treated vertebra significantly increased compared with that before the operation (P < 0.05). MC with good osteogenic activity and degradation properties can effectively improve the mechanical properties and biocompatibility of the PMMA bone cement, thus obtain better clinical results.