Glycosylated hemoglobin and plasma protein in newborns of normal and diabetic women

Abstract

The glycosylated hemoglobin (glyco Hb) and the glycoprotein of the plasma were determined using affinity chromatographic techniques in cord blood and maternal blood of normal (Group I), White's Class A diabetic (Group II), and insulin-dependent diabetic (Group III) mothers. The results revealed significant increase of glyco Hb (P < 0.005) and glycoprotein (P< 0.005) in the newborns of Group III mothers in comparison to those of Group I. The glyco Hb of maternal blood in, this group also showed significant increase (P< 0.005) while the increase in Hb A, and plasma glycoprotein were nonsignificant. AH values for cord blood and maternal blood of White's Class A diabetics revealed no significant change from the normal group. We conclude that the fetuses of insulin-dependent diabetic mothers are hyperglycemic in utero. © 1984 International Pediatrics Research Foundation, Inc.