Systematic review of the Listeria monocytogenes σ regulon supports a role in stress response, virulence and metabolism

Abstract

Aim: Among the alternative sigma factors of Listeria monocytogenes, σ controls the largest regulon. The aim of this study was to perform a comprehensive review of σ-regulated genes, and the functions they confer. Materials & methods: A systematic search of PubMed and Web of Knowledge was carried out to identify members of the σ regulon based on experimental evidence of σ-dependent transcription and presence of a consensus σ-dependent promoter. Results: The literature review identified σ-dependent transcription units encompassing 304 genes encoding different functions including stress response and virulence. Conclusion: Our review supports the well-known roles of σ in virulence and stress response and provides new insight into novel roles for σ in metabolism and overall resilience of L. monocytogenes.