Synthesis and biological evaluation of novel 2-(1H-imidazol-2-ylmethylidene)hydrazinyl- 1,3-thiazoles as potential antimicrobial agents

Abstract

Synthesis, characterization, and investigation of antimicrobial activities of nine novel imidazolylthiazoles are presented. Their structures were determined using 1 H NMR, 13 C NMR, and elemental analysis. Compounds 3e and 3i show very strong or strong bacteriostatic or bactericidal activity [minimal bactericidal concentration/minimal inhibitory concentration (MIC)=2-64] against Staphylococcus spp. (MIC=7.81-15.62 μg/mL), Micrococcus luteus ATCC 10240 (MIC=1.95-3.91 μg/mL), and Bacillus spp. (MIC=3.91-15.62 μg/mL). Compounds 3e and 3i also show the highest fungicidal effect (minimal fungicidal concentration/MIC=2-4) against reference strains of fungi belonging to Candida spp. with MIC ranging from 3.91 to 31.25 μg/mL.