Value of Dual-energy CT Cerebral Perfusion Imaging Combined with FGF21 in the Diagnosis of the Severity of Cerebral Infarction

Abstract

This study aimed to reveal the value of dual- energy CT (DECT) cranial perfusion imaging combined with fibroblast growth factor 21 (FGF21) in the diagnosis of the severity of cerebral infarction. 100 patients with acute cerebral infarction were examined by DECT cranial perfusion imaging to obtain relative cerebral blood flow (rCBF) and relative cerebral blood volume (rCBV). Plasma fibroblast growth factor 21 (FGF21) levels in 100 patients and 30 healthy subjects were detected by enzyme-linked immunosorbent assay (ELISA). Patients were classified as mild, moderate, and severe according to the National Institutes of Health stroke scale (NIHSS) score. The diagnostic value of each parameter on the severity of cerebral infarction was analyzed by receiver operating characteristic (ROC). The levels of rCBF and rCBV decreased with the increase of cerebral infarction severity (P<0.05). With the increase of the severity of cerebral infarction, the level of plasma FGF21 increased gradually (F=65.212, P=0.002). The AUC, sensitivity and specificity of rCBF and rCBV combined with plasma FGF21 in diagnosing the severity of cerebral infarction were 0.955, 84.91% and 95.74%, respectively. The diagnostic value of rCBF and rCBV combined with plasma FGF21 for the severity of cerebral infarction is higher than that of single diagnosis.