Cerebrospinal Fluid Alzheimer's Disease Biomarkers in Isolated Supratentorial Cortical Superficial Siderosis

Abstract

We evaluated cerebrospinal fluid amyloid-β 1-40 (Aβ40), amyloid-β 1-42 (Aβ42), total and phosphorylated-tau (t-tau and p-tau) in patients with symptomatic isolated cortical supratentorial superficial siderosis (SS), by prospectively recruiting ten patients with SS in the absence of pre-existing cognitive dysfunction, and comparing biomarkers with lobar hematoma cerebral amyloid angiopathy patients (LH-CAA, n=13), Alzheimer's disease patients (AD, n=42), and controls (n=16). Compared to controls, SS patients showed statistically significant higher t-tau (p=0.019) and lower Aβ42 (p=0.0084). Compared to other groups, SS showed statistically significant lower t-tau, p-tau, and Aβ40 compared to AD (p=0.0063, p=0.0004, and p=0022, respectively), and higher p-tau compared to LH-CAA (p=0.012).