A novel triacylglycerol from a cytotoxic extract of a red sea marine fungus

Abstract

INVESTIGATION of the CH2l2 extract of a taxonomically unidentified anamorphic fungus strain MF 014, has yielded the glycerol triester, 1,3-O-bis-Z-ll-eicosenoyl 2-O-Z-9, Z-12-nonadecadienoyl glycerol. The structure of this novel metabolite was established on the basis of extensive 1D- and 2D-NMR spectroscopic studies as well as on mass spectrometric analysis. The extract exhibited in vitro cytotoxic activity against human amniotic epithelial cells (FL cells) in the neutral red assay.