Progress in metal-catalysed trifluormethylation reactions using hypervalent iodine reagents

Abstract

The trifluoromethyl group is found in a variety of pharmaceuticals, agrochemicals, and functional organic compounds due to its ability to improve properties like electronegativity, hydrophobicity, metabolic stability, binding selectivity, and bioavailability. As a result, the development of innovative techniques for the incorporation of trifluoromethyl group has long been a research focus. Various metals such as Cu, Mg, Ni, Ag, Fe, and V were found to act as lewis acid in the synthesis of different trifluoromethylated compounds. In this review, the recent development of metal-catalyzed trifluoromethylation of C-C, C-N, C-O multiple/single bonds using hypervalent iodine reagent is described.