Major histocompatibility complex gene polymorphism in systemic lupus erythematosus patients

Abstract

The major histocompatibility complex (MIC) is one of the MHC class I related genes which related with autoimmune diseases, the present study aims to investigated association between MIC gene polymorphism class I in systematic lupus erythrymatous patients within Hilla city, the present study implemented using whole blood genomic DNA and single strand DNA conformation polymorphism (SSCP) for detection gene polymorphisms and haplotypes frequency, The results of present study show that 183 bp of MIC gene and it has three haplotypes (A, B, and C) each of these haplotypes consist of two bands, non-significant differences between patient and control in haplotypes frequency, B haplotype was more frequent in patinas than others (20%) while A was more frequents in control than others (22.8%). The present study concluded that MIC gene may be contributed in immune response of SLE and can be used in pre diagnosis of disease. This study was one of the serious investigators deal with several immune genes in this disease in Iraqi SLE.