Antibiotic resistance and serotype distribution of Shigella strains in Bangladesh over the period of 2014–2022: evidence from a nationwide hospital-based surveillance for cholera and other diarrheal diseases

Abstract

This nationwide study in Bangladesh assessed Shigella infections from 2014 to 2022 from clinical samples. S. flexneri was predominant, with concerning antibiotic resistance, notably to ciprofloxacin and nalidixic acid in over 96% of isolates. This emphasizes the urgency of prudent antibiotic use and improved hygiene. The findings provide crucial antimicrobial resistance patterns of Shigella species, highlighting the need for ongoing resistance monitoring and potentially informing future vaccine trials.