Experimental models of metabolic syndrome in rats

Abstract

Metabolic syndrome (MS) is one of the most significant problems of modern society. Rapidly growing prevalence of MS results in high morbidity and mortality due to its vascular complications. Experimental studies can help us to understand the underlying mechanisms of MS development and progression, as well as to develop potential therapeutic interventions. MS represents a multifactorial complex of pathological changes and the selection of an appropriate experimental model is crucial in investigation of this condition. In this review, we will discuss the most common genetic animal models of MS, along with the models in which MS is caused by exogenous factors.