Inhibition of cancer cell migration and invasion through suppressing the wnt1-mediating signal pathway by G-quadruplex structure stabilizers

Abstract

Background: The Wnt1 pathway is recognized to play a major role in cancer progression. Results: The promoter region of the WNT1 gene can form G-quadruplex structures, which regulate WNT1 expression and its downstream signaling pathways. Conclusion: The Wnt1-mediated migration and invasion activities of cancer cells are inhibited by G-quadruplex stabilizers. Significance: A pathway-specific strategy is identified to repress cancer metastasis using G-quadruplex stabilizers. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.