MiR-29a inhibits the progression of oral squamous cell carcinoma by targeting Wnt/β-catenin signalling pathway

Abstract

Aim: The study aimed to investigate the role of miR-29a in the progression of oral squamous cell carcinoma (OSCC), as well as its molecular mechanism. Methods: Tissue samples were collected from 103 OSCC patients. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the relative expression of miR-29a in OSCC tissues and cell line. Cell proliferation, motility and apoptosis were detected using MTT, transwell and flow cytometry methods, respectively. Western blot was used to measure the protein expression. Results: The expression of miR-29a was decreased in OSCC tissue and cells (p