Treatment failure of methicillin-resistant Staphylococcus aureus endocarditis with linezolid

Abstract

We report a case of methicillin-resistant Staphylococcus aureus endocarditis treated by vancomycin and cotrimoxazole switched to oral linezolid alone with a complete resolution of the vegetation. Two months after discontinuation of treatment, the patient presented a relapse confirmed by pulsed-field gel electrophoresis involving the same linezolid-susceptible strain and rapidly died. © 2005 Taylor & Francis.