A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions

Abstract

Apicomplexan proteomes are substantially specific to these parasites, and many cellular compartments are highly specialized. Using spatial proteomic methods, Barylyuk et al. simultaneously map the locations of thousands of Toxoplasma proteins, resolving the genomic complexity of this pathogen within the context of its cell organelles, compartments, and structures.