Synthesis of 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent

Vandana Srivastava; Arvind S. Negi; J. K. Kumar; Uzma Faridi; Brijesh S. Sisodia; M. P. Darokar; Suaib Luqman; S. P.S. Khanuja

Journal Article

Synthesis of 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent

Bioorganic and Medicinal Chemistry Letters (2006) 16(4) 911-914

DOI: 10.1016/j.bmcl.2005.10.105

125Citations

34Readers

Get full text

Abstract

3′,4′,5′-Trimethoxy benzoyl-naphthalene 2-O-acetic acid (5) underwent base catalysed intramolecular condensation to yield exclusively 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1-b]furan 8. The cyclised product 8 has been characterised by spectroscopy. The product 8 showed significant anticancer activity against human cancer cell lines COLO320DM (colon), CaCO2 (colon) and WRL68 (liver) at 0.7, 0.65 and 0.50 μg/ml concentrations, respectively, in the in vitro MTT assay. © 2005 Elsevier Ltd. All rights reserved.

Author supplied keywords

Cite

CITATION STYLE

APA

Srivastava, V., Negi, A. S., Kumar, J. K., Faridi, U., Sisodia, B. S., Darokar, M. P., … Khanuja, S. P. S. (2006). Synthesis of 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent. Bioorganic and Medicinal Chemistry Letters, 16(4), 911–914. https://doi.org/10.1016/j.bmcl.2005.10.105

Synthesis of 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent

Abstract

Author supplied keywords

Cite

Register to see more suggestions