Development of enzymatic sensors based on extended-gate-type organic field-effect transistors

Abstract

Organic field-effect transistors (OFETs) are promising platforms for flexible and disposable sensors, because of their attractive properties such as mechanical stretchability, environmental friendliness, compact integration, and solution processability. Although physical sensors utilizing OFETs have been successfully demonstrated, the development of OFET-based chemical/bio-sensors is still in its infancy. In this regard, we have designed new enzyme-modified OFETs with electron mediators for selective analyte sensing. The fabricated OFET with an extended-gate electrode can reproducibly operate under ambient conditions. Importantly, the developed OFET successfully detected analytes such as nitrate, lactate, and biogenic amines in pseudo and real biological fluids. Thus, we believe that the proposed approach to develop OFET-based enzymatic sensors will open up new avenues for the realization of practical and flexible biosensing applications.