Hepatoprotective activity of mangrove snail (Telescopium sp.) extract in sprague dawley rats induced by paracetamol

Abstract

The preliminary study showed that mangrove snails contain bioactive compounds and possess antioxidant activity, whereas these snails are only considered as pond pests. This study aimed to determine the activity of mangrove snails (Telescopium sp.) as hepatoprotective in Sprague Dawley rats induced by paracetamol. This study used a completely randomized design (CRD) with Duncan's follow-up test, where mice were divided into 6 treatment groups (with n = 3). The observations included the levels of enzyme serum Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and, malondialdehyde (MDA), and histopathological tissue. The results of histopathological analysis showed that dose of 75 mg/kg body weight were protective and repair on rat liver tissue.