Synthesis and degradation of Schiff bases containing heterocyclic pharmacophore

Abstract

This paper reports on the synthesis and characterization of two Schiff bases bearing 1,2,4-triazolic moieties, namely 4H-4-(2-hydroxy-benzylidene-amino)-5-benzyl-3- mercapto-1,2,4-triazole and 4H-4-(4-nitro-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4- triazole using thin layer chromatography, melting interval, elemental analysis, spectroscopy and thermal stability studies.