The evolving landscape of glioblastoma stem cells

Abstract

Brain cancers activate core stem cell regulatory pathways to empower self-renewal, maintenance of an organ system (albeit an aberrant one), and survival under stress that collectively permits tumor growth, therapeutic resistance, invasion, and angiogenesis. These properties have implicated CSCs as contributors in GBM progression and recurrence, spurring a search for anti-CSC therapies that do not disrupt normal stem cell maintenance. The last year has witnessed a rapid evolution in the understanding of CSC biology to inform preclinical targeting. © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited.