Thioflavin-T: A versatile optical probe for chemo and biosensing

Abstract

Sensing of chemical and biological molecules using extrinsic fluorescence probes has gained a lot of attention in contemporary research due to their high sensitivity and selectivity towards wide array of analytes. In this review article, we have focused on the photophysical properties of Thioflavin-T and their subsequent modulations in presence of various different class of analytes which enable sensitive detection of different molecules. The versatility of Thioflavin-T, as fluorescent probe, is well exhibited by its ability to interact with various molecules which, in turn, act as direct or indirect platforms for detection of both biological and chemical molecules. Through, this short review, we aim to encourage other researchers to further explore the interesting photophysical properties of Thioflavin-T for sensing other clinically important biological and chemical analytes.