Act1, an NF-κB-activating protein

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Abstract

Use of an NF-κB-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-κB activator. Act1 associates with and activates IκB kinase (IKK), leading to the liberation of NF-κB from its complex with IκB. Many signaling pathways that liberate NF-κB also activate activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). Act1 also activates JNK, suggesting that it might be part of a multifunctional complex involved in the activation of both NF-κB and JNK. Act1 fails to activate NF-κB in an IL-1-unresponsive mutant cell line in which all known signaling components are present, suggesting that it interacts with an unknown component in IL-1 signaling.

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Li, X., Commane, M., Nie, H., Hua, X., Chatterjee-Kishore, M., Wald, D., … Stark, G. R. (2000). Act1, an NF-κB-activating protein. Proceedings of the National Academy of Sciences of the United States of America, 97(19), 10489–10493. https://doi.org/10.1073/pnas.160265197

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