Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species

Abstract

A collection of clinical (n 47) and environmental (n 79) Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 g/ml, respectively, compared with 0.51 g/ml for micafungin, 0.85 g/ml for efinaconazole, 1.12 g/ml for natamycin, 1.18 g/ml for anidulafungin, 1.31 g/ml for voriconazole, 1.35 g/ml for caspofungin, 1.9 g/ml for amphotericin B, and 4.08 g/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of skin and nail infections due to Fusarium species.