Antibacterial action of (5-nitrofurfuryl)-derived aminophosphonates and their parent imines

Abstract

Abstract: Ten aminophosphonates bearing 2-nitrofuran moiety and two N-aryl 5-nitro-furfuralaldimines, namely, N-(2-nitrofurfurylidene)-p-toluidine and N-(2-nitrofurfurylidene)-p-anisidine, were tested in aspect of their antibacterial action. O,O′-diphenyl derivatives were found inactive, while O,O′-dimethyl and O,O′-diethyl derivatives were revealed to act moderately efficiently against clinical isolates of S. aureus, especially against methicillin-resistant (MRSA) strains. A high activity against these strains was found for N-(4-methylphenyl)-5-nitrofurfuralaldimine and N-(4-methoxyphenyl)-5-nitro-furfuralaldimine, but they showed the cytotoxicity at a dangerous level. Graphical abstract: [Figure not available: see fulltext.].