Identifying obesity-related multimorbidity combinations in the United States

Abstract

Interest in understanding the effects of multimorbidity on outcomes has increased in recent years. This paper presents the most common obesity-related groupings of multimorbidity in the United States. Using Cerner HealthFacts data, we applied the frequent pattern growth algorithm to identify prevalent multimorbidity groupings of 3 or more diseases (one being obesity) by race using a dataset of 574 172 patients with obesity from all over the United States. We set the minimum prevalence to 10% and identified groupings of ICD10-CM diagnoses that occur in our dataset at or above the minimum prevalence level. We provide binomial proportion confidence interval estimates to demonstrate the validity of the proportions. We performed g-test for independence to validate differences in prevalence by race. We found 18 multimorbidity combinations with prevalence higher than or equal to 10%. Our results indicate that there are multiple common multimorbidities groupings for patients with obesity. Each multimorbidity combination is composed of diseases from the following clinical categories: endocrine, nutritional and metabolic diseases; diseases of the circulatory system; diseases of the digestive system; diseases of the nervous system; and diseases of the musculoskeletal system and connective tissue. For each multimorbidity pattern, the prevalence was found to be significantly different by race according to the g-test with P-value