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SURVEY AND SUMMARY: The applications of universal DNA base analogues

  • Loakes D
Nucleic Acids Research (2001) 29(12) 2437-2447
DOI: 10.1093/nar/29.12.2437
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Abstract

A universal base analogue forms 'base pairs' with each of the natural DNA/RNA bases with little discrimination between them. A number of such analogues have been prepared and their applications as biochemical tools investigated. Most of these analogues are non-hydrogen bonding, hydrophobic, aromatic 'bases' which stabilise duplex DNA by stacking interactions. This review of the literature of universal bases (to 2000) details the analogues investigated, and their uses and limitations are discussed.

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Loakes, D. (2001). SURVEY AND SUMMARY: The applications of universal DNA base analogues. Nucleic Acids Research, 29(12), 2437–2447. https://doi.org/10.1093/nar/29.12.2437

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