P-113THE IMPACT OF EARLY ORAL FEEDING ON HIGH-MOBILITY GROUP BOX CHROMOSOMAL PROTEIN 1 AFTER McKEOWN MINIMALLY INVASIVE OESOPHAGECTOMY FOR CANCER

Abstract

Objectives: The aim of current study was to investigate the impact of early oral feeding (EOF) on high‐mobility group box chromosomal protein 1 (HMGB‐1) after McKeown minimally invasive oesophagectomy (MIE) for cancer Methods: This study was based on a single centre randomized controlled trial in Henan Cancer Hospital (NCT01998230). Patients with oesophageal cancer who received McKeown MIE were randomly allocated to a group starting EOF on postoperative day (POD) 1 and another group that remained nil by mouth until 7 days after surgery (late oral feeding, LOF group). A total of 280 patients were included in this study. We chose 46 patients including 25 patients in EOF group and 21 patients in LOF group to test HMGB‐1. Serum HMGB‐1 concentrations were measured by enzyme‐linked immunosorbent assay. Blood samples were obtained before, and at POD1, POD3 and POD5. HMGB‐1 changes between the 2 groups and within groups were evaluated. Results: EOF group and LOF group exhibited similar preoperative HMGB‐1 level. The level of HMGB‐1 increased significantly at POD1 and POD3 compared with preoperative level (all P < 0.01). At POD5 the level of HMGB‐1 decreased compared with POD1 and POD3. At PODs 3 and 5, the level of HMGB‐1 in the EOF group was significantly lower than those in the LOF group (all P < 0.05). Conclusions: Compared to conventional rehabilitation program, EOF could decrease HMGB‐1 after McKeown MIE.