Evaluation of a new dynamic viscometer for measuring the viscosity of whole blood and plasma

Abstract

We evaluated a new type of dynamic viscometer, the Sonoclot Coagulation Analyzer, for use in measuring the viscosity of whole-blood and plasma. Such information can be useful in monitoring patients with hyperviscosity syndromes, e.g., from multiple myeloma. A vibrating Teflon or plastic probe continuously measures synamic viscosity. The instrument can be calibrated to measure a range of viscosities from 0.69 to 23 cP (mN · s · m-2) or more. The coefficient of variation at 0.69 cP was 3-4% for measurements with Teflon probe, 7-9% with the plastic probe. Viscosity measured at 37°C for plasma and whole-blood samples from 20 normal patients was 1.22 (SD 0.05) cP and 3.63 (SD 0.52) cP, respectively. Dynamic viscosity measured in blood samples from a single source, with contrived hematocrits ranging from 0 to 89%, increased exponentially as a function of hematocrit, confirming previous studies. Overall, we found this instrument simple and quick to operate, producing accurate, precise viscosity measurements over at least a 40-fold range of viscosity.