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To PARP or not to PARP?—Toward sensitizing acute myeloid leukemia stem cells to immunotherapy

  • Heyman B
  • Jamieson C
The EMBO Journal (2019) 38(21)
DOI: 10.15252/embj.2019103479
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Abstract

A new study reveals that leukemia stem cells (LSCs) in acute myeloid leukemia downregulate natural killer cell-activating receptor ligands to evade immune surveillance via the transcriptional co-factor PARP1. The inhibition of PARP1 sensitizes LSCs to immunotherapy, highlighting its potential as a therapeutic target.

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Heyman, B., & Jamieson, C. (2019). To PARP or not to PARP?—Toward sensitizing acute myeloid leukemia stem cells to immunotherapy. The EMBO Journal, 38(21). https://doi.org/10.15252/embj.2019103479

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