Wnt signalling in lung development and diseases

Abstract

There are several signalling pathways involved in lung organogenesis including Notch, TGFβ/BMP, Sonic hedgehog (Shh), FGF, EGF, and Wnt. Despite the widely acknowledged significance of Wnt signalling in embryonic lung development, the role of different Wnt pathways in lung pathologies has been slow to emerge. In this review, we will present a synopsis of current Wnt research with particular attention paid to the role of Wnt signals in lung development and in pulmonary disease. © 2006 Pongracz and Stockley; licensee BioMed Central Ltd.