Activation and stabilization of drugs by supramolecular pKa shifts: Drug-delivery applications tailored for cucurbiturils

Abstract

(Graph Presented) Controlling the drug supply: UV and NMR spectroscopic studies show that drugs such as omeprazole and lansoprazole, popular drugs for the treatment of gastric acid related diseases, are stable for several weeks by using cucurbit[7]uril as a macrocyclic host (see scheme). The drugs are also more rapidly converted into their active forms by an acid-promoted reaction catalyzed by a supramolecular pKa shift. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.